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Robot Check. Enter the characters you see below. Sorry, we just need to make sure you're not a robot. For best results, please make sure your browser is accepting cookies. Ni. Quitin 2. 1 mg transdermal patches - Summary of Product Characteristics (SPC)Ni. Quitin 2. 1mg transdermal patches. Each 2. 2cm. 2 transdermal patch contains 1. For excipients, see section 6. Transdermal patch. Each patch is rectangular and is comprised of an outer matt pinkish tan- coloured layer, a middle silver layer and an outer clear layer which is removed prior to use. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. Transdermal drug delivery: principles and opioid therapy. There are two designs of transdermal patch currently available. Pharmacokinetics of transdermal drug delivery; Transdermal delivery systems. Nicotine, transdermal patch, releasing 15 mg per 16 hours, Nicorette NiQuitin 21 mg transdermal patches - Summary of Product Characteristics. Plasma concentrations of nicotine are proportional to dose for the three dosage forms of NiQuitin. Ni. Quitin patches relieve and/or prevent craving and nicotine withdrawal symptoms associated with tobacco dependence. They are indicated to aid smokers wishing to quit or reduce prior to quitting, to assist smokers who are unwilling or unable to smoke, and as a safer alternative to smoking for smokers and those around them. Ni. Quitin patches are indicated in pregnant and lactating women making a quit attempt. If possible, when stopping smoking, Ni. Quitin patches should be used in conjunction with a behavioural support programme. Ni. Quitin patches should be applied once a day, at the same time each day and preferably soon after waking, to a non- hairy, clean, dry skin site and worn continuously for 2. Users should be encouraged to stop smoking completely as soon as possible. If users are still feeling the need to use the patches on a regular basis 6 months after the start of treatment and have still been unable to undertake a permanent quit attempt, then it is recommended to seek additional help and advice from a healthcare professional. Temporary Abstinence Apply a patch to control troublesome withdrawal symptoms including craving during the period when smoking is being avoided. Users should be encouraged to stop smoking completely as soon as possible. If users are still feeling the need to use the patches on a regular basis 6 months after the start of treatment and have still been unable to undertake a permanent quit attempt, then it is recommended to seek additional help and advice from a healthcare professional. Where adolescents are not ready or not able to stop smoking abruptly, advice from a healthcare professional should be sought. Safety and effectiveness in children who smoke has not been evaluated. Ni. Quitin is not recommended for use in children under 1. Ni. Quitin is contraindicated in patients with hypersensitivity to the system, the active substance, or any of the excipients. Ni. Quitin patches should not be used by non- smokers, occasional smokers or children under 1. The risks associated with the use of NRT are substantially outweighed in virtually all circumstances by the well established dangers of continued smoking. Patients hospitalised for MI, severe dysrhythmia or CVA who are considered to be haemodynamically unstable should be encouraged to stop smoking with non- pharmacological interventions. If this fails, Ni. Quitin patches may be considered, but as data on safety in this patient group are limited, initiation should only be under medical supervision. Once patients are discharged from hospital they can use NRT as normal. If there is a clinically significant increase in cardiovascular or other effects attributable to nicotine, the nicotine patch dose should be reduced or discontinued. Diabetes: Blood glucose levels may be more variable when stopping smoking, with or without NRT as catecholamines released by nicotine can affect carbohydrate metabolism, so it is important for diabetics to monitor their blood glucose levels more closely than usual while using this product. Allergic reactions: Susceptibility to angioedema and urticaria. Atopic or eczematous dermatitis (due to localised patch sensitivity): In the case of severe or persistent local reactions at the site of application (e. Danger in small children: Doses of nicotine tolerated by adult and adolescent smokers can produce severe toxicity in small children that may be fatal. Products containing nicotine should not be left where they may be misused, handled or ingested by children. The patches should be folded in half with the adhesive side innermost and disposed of with care. Stopping smoking: Polycyclic aromatic hydrocarbons in tobacco smoke induce the metabolism of drugs catalysed by CYP 1. A2 (and possibly by CYP 1. A1). When a smoker stops this may result in a slower metabolism and a consequent rise in blood levels of such drugs. Transferred dependence: Transferred dependence is rare and is both less harmful and easier to break than smoking dependence. Safety on handling: Ni. Quitin is potentially a dermal irritant and can cause contact sensitisation. Care should be taken during handling and in particular contact with the eyes and nose avoided. After handling, wash hands with water alone as soap may increase nicotine absorption. No clinically relevant interactions between nicotine replacement therapy and other drugs has definitely been established, however nicotine may possibly enhance the haemodynamic effects of adenosine. However, if the mother cannot (or is considered unlikely to) quit without pharmacological support, NRT may be used as the risk to the foetus is lower than that expected with smoking tobacco. Stopping completely is by far the best option but NRT may be used in pregnancy as a safer alternative to smoking. Because of the potential for nicotine- free periods, intermittent dose forms are preferable, but patches may be necessary if there is significant nausea and/or vomiting. If patches are used they should, if possible, be removed at night when the foetus would not normally be exposed to nicotine. Lactation. The relatively small amounts of nicotine found in breast milk during NRT use are less hazardous to the infant than second- hand smoke. Intermittent dose forms would minimize the amount of nicotine in breast milk and permit feeding when levels were at their lowest. NRT may cause adverse reactions similar to those associated with nicotine administered by other means, including smoking. These may be attributable to the pharmacological effects of nicotine, some of which are dose dependent. At recommended doses, Ni. Quitin patches have not been found to cause any serious adverse effects. Excessive use of Ni. Quitin patches by those who have not been in the habit of inhaling tobacco smoke could possibly lead to nausea, faintness or headaches. Subjects quitting smoking by any means could expect to suffer from asthenia, headache, dizziness, sleep disturbance, coughing or influenza- like illness. Certain symptoms which have been reported such as depression, irritability, nervousness, restlessness, mood lability, anxiety, drowsiness, impaired concentration and insomnia may be related to withdrawal symptoms associated with smoking cessation. Application site reactions are the most frequent adverse reaction associated with Ni. Quitin. Ni. Quitin can cause other adverse reactions related to the pharmacological effect of nicotine or withdrawal effects related to smoking. The following undesirable effects have been reported in clinical trials or spontaneously post- marketing. Certain symptoms which have been reported such as depression, irritability, nervousness, restlessness, mood lability, anxiety, drowsiness, impaired concentration, insomnia and sleep disturbances may be related to withdrawal symptoms associated with smoking cessation. Subjects quitting smoking by any means could expect to suffer from asthenia, headache, dizziness, coughing or influenza- like illness. Immune System Disorders. Uncommon> 1/1. NOS*Very rare < 1/1. Psychiatric. Very common > 1/1. Common > 1/1. 00; < 1/1. Nervous system disorders. Very Common > 1/1. Common > 1/1. 00; < 1/1. Not known: seizures. Cardiac disorders. Common > 1/1. 00; < 1/1. Uncommon > 1/1. NOSRespiratory, Thoracic and Mediastinal Disorders. Common > 1/1. 00; < 1/1. Gastrointestinal Disorders. Very Common > 1/1. Common > 1/1. 00; < 1/1. NOS, dry mouth, constipation. Skin and Subcutaneous Tissue Disorders. Common > 1/1. 00; < 1/1. Very rare > 1/1. Musculoskeletal and Connective Tissue Disorders. Common > 1/1. 00; < 1/1. General Disorders and Administration Site Conditions. Very Common > 1/1. NOS*Common > 1/1. NOS, asthenia, fatigue. Uncommon > 1/1. Application site reactions, including transient rash, itching, burning, tingling, numbness, swelling, pain and urticaria are the most frequent undesirable effects of Ni. Quitin patch. In the case of severe or persistent local reactions at the application site (e. Suspected nicotine poisoning in a child should be considered a medical emergency and treated immediately. Prostration, hypotension, respiratory failure, rapid or weak or irregular pulse, circulatory collapse and convulsions (including terminal convulsions) may ensue with large overdoses. Management Overdose from Topical Exposure. The nicotine patch(es) should be removed immediately in the event of an overdose or if the patient shows signs of overdosage. The user should seek medical attention immediately. The patient should seek medical attention immediately and be treated symptomatically. Artificial respiration with oxygen should be instituted if necessary. Withdrawal from nicotine in addicted individuals is characterised by craving, nervousness, restlessness, irritability, mood lability, anxiety, drowsiness, sleep disturbances, impaired concentration, increased appetite, minor somatic complaints (headache, myalgia, constipation, fatigue) and weight gain. Withdrawal symptoms, such as cigarette craving, may be controlled in some individuals by steady- state plasma levels lower than those for smoking. In clinically controlled trials, Ni. Quitin was shown to alleviate nicotine withdrawal symptoms as well as craving. Ni. Quitin reduced the severity of cravings by at least 3. Absorption. Following transdermal application, the skin rapidly absorbs nicotine released initially from the patch adhesive. The plasma concentrations of nicotine reach a plateau within 2- 4 hours after initial application of Ni. Quitin with relatively constant plasma concentrations persisting for 2. Program Overview. Commission Notes: * These are starting commission levels. ![]() You can earn more by qualifying as a TAAP preferred partner! Contact us to find out more about our fabulous incentive scheme. We accept any one of the following: IATA (IATAN)ARCCLIATrue IDOther (requires all four of the below): A letter of request on your own agencys letterhead declaring why you are seeking this direct relationship. Copies of your state or local business licenses. Your federal employer ID number. Proof of errors and omissions insurance. ![]() ![]() ![]() Expedia Affiliate Network - Quick Travel Affiliate. 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